Psalm 127

Unless the Lord builds the house,
They labor in vain who build it;
Unless the Lord guards the city,
The watchman stays awake in vain. v.1

Read chapter 127
Nisi Dominus Frusta a Latin motto that means 'without the Lord, frustration.'  Notice this psalm is by Solomon who was also the author of Ecclesiastes which tag line throughout that whole book is everything is vain, meaningless.  
Any labor that God Himself has not built is in vain.  Now that doesn't mean whatever you're working in has to be a Christian company or it's vain, but to ask ourselves is our labor for the Lord as if He's our only boss? 
The rest of the psalm goes on to talk about family and this too we can see this first verse play through.  Unless the Lord builds the family...  How often do people seek a spouse that isn't from the Lord, settling just to be married only to end up divorced or stuck later?  That's not to say that God can't work a miracle and make it into a beautiful thing of two becoming one nor is it to say their children are in vain, but if the family isn't being built and growing by God, what's the point.  God is a custom builder and we shouldn't allow ourselves to think our home should look like anyone else's.   God is the architect and He alone has the blueprints.  What or how have you tried building and found it senseless or futile?